Network reconstruction of the predicted relationships between molecules as inferred from gene expression changes reveal that GPC1-low patients reveals inhibition of linchpin regulators positively associated with cancer maintenance and progression, including transforming growth factor beta 1 (TGFβ), p38 MAPK, AKT, and PDGF-BB, interferon-α and WNT [For review see 1, 9, 10, 31, 32] (Figure 7B). This evidence concerns the gene AKT1 and cancer.