TGFB1 and colorectal cancer: According to GSEA, the expression of FAM135A is positively correlated to the pathways of colorectal cancer, glioma, JAK-STAT signal, MAPK signal, pancreatic cancer, cancer, prostate cancer, renal cell carcinoma, TGF-BETA signal pathway, WNT signal, and negatively correlated to the pathways of Huntington’s disease, Parkinson’s disease, oxidative phosphorylation, and ribosome, as shown in Fig. 6B. GSEA analysis revealed that the genes associated with FAM135A were mainly enriched in JAK-STAT signal related pathways (Fig. 6C).