Our current study has limitations: (1) our mouse model only mimics hyperglycemia induced by insulin deficiency but not insulin resistance which is also observed in preterm infants; (2) the underlying mechanisms behind FGF21 regulation of TFEB pathway and lipid metabolism need to be further explored; (3) in the clinical study, the analyses of nutrient intake in preterm infants were not adjusted for GA and BW due to the small number of patients. The gene discussed is TFEB; the disease is Insulin resistance.