FLNC and chronic obstructive pulmonary disease: Phenotypically, variants in the corresponding FLNC gene cause skeletal muscle disorders such as myofibrillar myopathy, distal myopathy and limb girdle muscular dystrophy, whereas associated cardiac defects mainly include dilated, restrictive and hypertrophic cardiomyopathies, and cardiac arrhythmias (Mao and Nakamura 2020).