Increasing density of tumor-infiltrating lymphocytes is associated with increased pCR rates in both hormone receptor positive and negative breast cancer.34-36 Virally suppressed people living with HIV demonstrate exhaustion of T cells, reducing their effector functions.37 Increased ratio of exhausted type infiltrating T cells has been associated with poorer overall survival among Black American patients with breast cancer.38 Perhaps HIV has a similar effect on patients with breast cancer, reducing tumor sensitivity to chemotherapy and likelihood of a pCR. The gene discussed is NR4A1; the disease is breast cancer.