We discovered that RHBDF2 expression is upregulated in HCC cell lines (HepG2, SK‐Hep1, Hep3B2.1‐7) according to the outcomes of RT‐qPCR and western blotting compared to normal liver cell line LO2 (Fig. 2E,F). This evidence concerns the gene RHBDF2 and hepatocellular carcinoma.