For example, the upregulation of RHBDF2 expression can promote the progression of cervical cancer by inducing TGF‐β transcription [23], RHBDF2 promotes the transport and activation of ADAM17 is the key to activating tumor necrosis factor signaling [35], RHBDF2 can mediate inflammation by releasing TNF‐α [22, 39, 40, 41, 42] and downregulation of RHBDF2 expression can lead to changes of cytokine production in T helper cells [43]. The gene discussed is ADAM17; the disease is cervical carcinoma.