Moreover, in mice, it was shown that GNAI1and GNAI3 suppress GNAI2-mediated colitis-associated tumorigenesisthrough negatively regulating Janus kinase (JAK) and NF-κB promotedIL-6 signaling.65 According to existingpathway data from reactome, we deem the pathway shown in Figure S1 to be relevant for the TAS2R-inducedintracellular signaling resulting in IL-6 gene transcription via NFκ-B.Moreover, the work by Zhou et al.10 showedthat heterotrimeric G-protein subunits PLCβ2 and GNAT3 are relevantin HGF-1 cells for their response to LPS. Here, GNAI2 is linked to colitis.