ADORA2B and neoplasm: Mining published RNA-seq data from 60 paired PDAC samples of stroma and tumor microdissections (GSE93326) (Maurer et al., 2019) and performing differential expression analysis, we observed that most genes related to high Winter hypoxia scores (P2RY2, ADORA2B, and NT5E) were expressed in the tumor epithelial tissue (Figure 1D), except for PANX1, encoding for pannexin 1, which is involved in cellular ATP release (Bao et al., 2004).