Studies on oral squamous cell carcinoma have shown that GPR39 mediates the regulation of p‐cofilin and FAK‐dependent signaling pathways to regulate the activation YAP (YAP/TAZ) primarily through the regulation of Gαq/11‐RhoA signaling but not Gα12/13 through the regulation of p‐cofilin and FAK (Figure 1).41 The gene discussed is CFL1; the disease is oral cavity squamous cell carcinoma.