A Zn‐supplemented diet (4‐week Zn‐loaded diet) significantly improved long‐term cognitive impairment induced by developmental seizures and upregulated GPR39 expression in the hippocampus, indicating that high‐Zn intervention may induce a protective effect against developmental epilepsy‐induced brain damage via the GPR39 pathway.66 This evidence concerns the gene GPR39 and Cognitive impairment.