After adjustment plus medical insurance, onset to door time, arrival modality, current smoking, hypertension, diabetes, hyperlipidemia, prior stroke/TIA, AF, CHD, heart failure, carotid stenosis, PVD, anticoagulant, antiplatelet, antihypertensive, lipid‐lowering agents, glucose‐lowering agents, stroke unit, SBP at admission, and TOAST subtype, we found IV t‐PA was still associated with improvement in NIHSS at discharge (aOR, 2.26; 95% CI, 1.73–2.96; p < 0.001). The gene discussed is PLAT; the disease is Stroke.