The post hoc analysis of the Efficacy and Safety of MRI‐based Thrombolysis in Wake‐up Stroke (WAKE‐UP) trial22 showed IV t‐PA brought an absolute increase of 12% of 90‐day favorable functional outcome compared with placebo in patients with lacunar infarcts and the median NIHSS score of five points on admission.23 This evidence concerns the gene PLAT and stroke disorder.