NCAM1 and diffuse large B-cell lymphoma: In addition, it has been suggested that CD56 expression in DLBCL could be related to a more frequent extranodal presentation associated to the adhesive properties of CD56.9,11 In neural cells, it mediates cell-to-cell adhesion by CD56 molecules of adjacent cells binding together.27 It may be involved in homophilic adhesion for NK and T cells due to the C2-set Ig regions and fibronectin regions within its extracellular domain.28 However, its function with respect to B-cell ontogeny is unclear.