RAC-alpha serine/threonine-protein kinase (AKT1), interleukin-6 (IL6), epidermal growth factor receptor (EGFR), vascular endothelial growth factor A (VEGFA), matrix metalloproteinase-9 (MMP9), transcription factor Jun (JUN), myc proto-oncogene protein (MYC), interleukin-1 beta (IL1B), and hypoxia-inducible factor 1-alpha (HIF1A) are most important genes in Leonuri Herba ‘s pharmacological effects on PCOS according to their degree. Here, HIF1A is linked to polycystic ovary syndrome.