The first proof of the pathogenic mechanisms in AD is the progressive extracellular aggregation of β-amyloid peptide (Aβ) in the brain and neurofibrillary tangles of the hyper-phosphorylated tau proteins inside neurons, influencing the advanced loss of hippocampal and cortical neurons and then initiating brain atrophy, followed by cognitive and memory loss [17]. Here, MAPT is linked to Alzheimer disease.