PRKN and Parkinson disease: Remarkably, genes like PINK-1 and Parkin, that are connected with Familial-Parkinson's disease partake in the regulation of mitochondrial dynamics and many other genetic mutations, such as Parkin, PINK-1, LRRK2, DJ-1, and α-Synuclein, have been related to familial PD and the resultant gene products also partake in mitophagy [25].