SERPING1 and Anxiety: For instance, 15 IU of C1-INH administered 1 h post-injury ameliorated brain injury, protected the BBB, attenuated inflammatory responses, and inhibited thrombus formation in a mouse cortical cryolesion model.13 Treatment with 15 IU of C1-INH 1 h after stroke also reduced infarct volumes and improved clinical scores in mice.14 C1-INH treatment accelerated recovery of body weight, attenuated anxiety-like behavior, and reduced the level of caspase-3 in a rat status epilepticus model.15