Given the potential significance of WBV for neural protection, we hypothesized that WBV may beneficially modulate the glial activation (known to be critically involved in AD pathology; see Rodríguez-Giraldo et al., 2022 for review [14]) and amyloid beta plaque formation in the hippocampus of transgenic human APP-J20 mice, a well-known model of AD [27]. The gene discussed is APP; the disease is Alzheimer disease.