NGF and pachyonychia congenita: On the other hand, when nerves lie more distally, exosomes represent a much more effient delivery system in promoting neo-neurogenesis, axogenesis, angiogenesis [142] and nerve infiltration of the tumour [143], given their ability to protect the cargo from the harsh TME pH, and to cover wide distances [9] Albeit the exosome-induced axonogenesis does not require NGF in PC [144], it has been recently shown that exosomes derived from PC patients with not favorable overall survival to Radium-223 are enriched of several oncogenic effectors, including NGF signaling components [145].