Findings collected over the last decade have highlighted the role of growth factors, including insulin-like growth factor-1 (IGF-1) [31, 32], vascular endothelial growth factor (VEGF) [33], epidermal growth factor (EGF) [34, 35] and their dependent networks in PC pathogenesis and progression. The gene discussed is VEGFA; the disease is pachyonychia congenita.