Subsequent univariate analysis confirmed that RA patients with Any PA had significantly increased CD11b expression on NDGs (MFI 6455 vs 5317, p = 0.014) and significantly lower expression of CD62L on NDGs (MFI 10,065 vs 12,676, p = 0.012), indicating neutrophil activation, as compared to No PA (Fig. 2B, C). This evidence concerns the gene ITGAM and rheumatoid arthritis.