We performed a prospective study to explore the relationship between urinary biomarkers and renal non-recovery in critically ill patients with AKI and analyze the accuracy of a novel urinary biomarker (CCL14) and first-generation urinary biomarkers ([TIMP-2] × [IGFBP7] and NGAL) for predicting non-recovery. The gene discussed is IGFBP7; the disease is acute kidney injury.