TIMP2 and acute kidney injury: Given the excellent performance of urine [TIMP-2] × [IGFBP7] in predicting AKI at high-risk populations, Zarbock et al. considered urine [TIMP-2] × [IGFBP7] ≥ 0.3 as inclusion criteria for intervention trial of the KDIGO bundle in a multicenter-center study enrolling 278 patients undergoing cardiac surgery and found a reduced occurrence of moderate and severe AKI in the intervention group compared with the control group [38].