reported that the activation of Notch signaling in hepatic parenchymal cells or nonparenchymal cells activates hepatic stellate cells and promotes the progression of liver fibrosis [10], while the inhibition of JAG1/Notch3 signaling alleviates the activation of hepatic stellate cells and the progression of liver fibrosis [11]. This evidence concerns the gene NOTCH3 and Hepatic fibrosis.