As mentioned above, BM-MSCs and BM-MSCsKD-EV transplantation alleviated liver inflammation, the DR, and collagen deposition; improved serum biochemical indexes; and decreased the Hyp content and the expression levels of proteins related to liver fibrosis, including α-SMA, TGF-β1 and Col(1). This evidence concerns the gene ACTA1 and Hepatic fibrosis.