In contrast, when log2 fold change (FC) was applied along with FDR, (e.g., − log10(FDR) > 2 and abs(log2FC > 2), the number of dots representing DEGs in the volcano plot of the tumors became larger than that of the NATs, indicating that the expression level of each gene within the tumor samples is more heterogeneous than NAT samples. This evidence concerns the gene BRD2 and neoplasm.