Consistently, Facista et al. [69] showed that early-stage colon cancer resection samples had a region (or NAT) with abnormally reduced expression of DNA repair enzyme genes (ERCC1, Pms2, and Xpf) when a series of approximately 15 sequential tissue sections (4 microns for each section) were examined. The gene discussed is LIG4; the disease is malignant colon neoplasm.