HDAC4 and systemic lupus erythematosus: Circ_0008360 inhibits FLS proliferation, migration and inflammation and promotes apoptosis by regulating the miR-135b-5p/HDAC4 axis in rheumatoid arthritis, providing a potential target for the prevention and treatment of RA [19].Circ_0000479 was found to be significantly up-regulated in patients with systemic lupus erythematosus (SLE) and may serve as a potential biomarker for its diagnosis [20, 21].