We found TUBA1C is a new potential target of LncRNA EGFR-AS1 promotes gastric cancer progression, the cancer-promoting function of lncRNA EGFR-AS1 in GC is partially mediated by heightening EGFR mRNA stability to active PI3K/AKT pathway and EGFR-AS1-TUBA1C interactions. This evidence concerns the gene TUBA1C and cancer.