The effect of ER on apoptosis has also been reported for other tissues: decreased Bax/Bcl-2 ratio in the liver and delayed aging [88], increased Bcl-2 and Bcl-2/Bax ratio, and suppression of neuroapoptosis in the brain after brain injury [89], increased Bcl-2 and Bcl-2/Bax ratio in the heart, and protection of the heart against ischemia [90]. Here, BCL2 is linked to ischemia.