Consistent with our results, it has been reported that the ER diet has a protective role against AKI by reducing the Bax/Bcl-2 ratio, ultimately reducing apoptosis [18, 66], and it has also been reported to prevent the increase in renal Bax and decrease in Bcl-2 and thus inhibit apoptosis in elder animals [41]. Here, BCL2 is linked to acute kidney injury.