Further reasons for the vulnerability caused by this type of diet, disruption of the oxidative balance system and an increase in proinflammatory cytokines such as TNF-α, IFN-γ, MCP-1, IL1β, and inflammatory conditions, decreased renal VEGF, increased intra-renal CD8 T cells, renin-angiotensin system imbalance, and insulin resistance, have been reported [73–77]. Here, CD8A is linked to Insulin resistance.