Therefore, in the regulatory network, we speculated that EVL directly regulated HLA-DPB1, HLA-DRA, MALAT1, and PFN1. As an upstream gene, MS4A7 regulates the expression of EVL. In conclusion, these results suggest that the downregulation of EVL leads to the downregulation of the expression of HLA family genes, which, in turn, results in reduced monocyte function and ultimately affects the prognosis of patients with sepsis. This evidence concerns the gene MALAT1 and Sepsis.