Variants encoding DBLα0-CIDRα2-6, DBLα1-CIDRα1, DBLα1-CIDRβ/γ/δ, DBLβ subtypes, and DBL3x domains have shown to be associated with cluster determinant 36 (CD36), endothelial protein C receptor (EPCR), complement receptor 1 (CR1), intercellular adhesion molecule 1 (ICAM1), and chondroitin sulphate A (CSA) binding, respectively, facilitating pathogenesis of severe malaria (Tessema et al. 2019; Obeng-Adjei et al. 2020). The gene discussed is CR1; the disease is malaria.