EGFR and glioblastoma: A diffuse astrocytic tumor without IDH mutation and without histone 3-alteration (H3 alteration) must be diagnosed as a glioblastoma, IDH wildtype with WHO tumor grade 4, if at least one of the following five histological and molecular features are present: microvascular proliferation and/or necrosis and/or EGFR gene amplification and/or TERT promotor mutation and/or +7/−10 chromosome copy number changes [23].