PDGFRA and central nervous system cancer: These tumors can be differentiated from adult-type high-grade gliomas by DNA methylome analysis and additionally, this analysis reveals three molecularly and prognostically distinct subgroups: one subgroup is characterized by frequent occurrence of amplifications of the gene for V-Myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MCYN amplification); another subgroup shows frequent PDGFRA amplifications and the last subgroup is characterized by frequent TERT promotor mutations or even EGFR amplifications.