WBC, B-cell, plasmacytoid (pDC), and conventional DC (cDC) counts were significantly reduced after LFPRLR knockdown, whereas counts of T cells and T-cell subsets (CD4+, CD8+, and pathologic CD4−CD8− SLE T cells) remained unaltered (Fig. 1c–e, Supplementary Fig. 2). This evidence concerns the gene CD4 and systemic lupus erythematosus.