LFPRLR knockdown killed Karpas-422 and SU-DHL-6 DLBCLs with half maximal inhibitory concentration (IC50) at 60–70 nM of LFPRLR SMO; however, IC50s for the VAL B-ALL and OCI-LY18 DLBCL cell lines were 20–40-fold higher (Fig. 5i, Supplementary Fig. 12). Here, SMO is linked to diffuse large B-cell lymphoma.