Considering that 14% of all NRXN2 mutations reported have resulted in both ASD and ASD-associated disorders (Supplemental Table 1), the Nrxn2 cKO mouse model is a valuable genetic tool to study biological pathways underlying the co-morbidity of ASD with epilepsy and other neurodevelopmental disorders [80]. Here, NRXN2 is linked to neurodevelopmental disorder.