DNASE1L3 and systemic lupus erythematosus: There are a significant number of SLE sera that are only positive for anti-dsDNA or anti-DNase1L3 antibodies, not all anti-DNase1L3 antibodies in serum were blocked by dsDNA, and we identified one anti-dsDNA monoclonal antibody (32.B9) with no reactivity to DNase1L3.