DNASE1L3 and systemic lupus erythematosus: While we found a striking association between anti-DNase1L3 and anti-dsDNA antibodies, which is explained in part by the presence of double reactive antibodies to DNase1L3 and dsDNA, it is puzzling that a recent study by Hartl et al.21 did not seem to support this finding, even though both studies found that antibodies to DNase1L3 were significantly linked to renal disease in SLE.