Considering that antibodies to dsDNA and C1q are present in up to 80% and 100% of patients with renal disease, respectively56, and that 72% of the patients had renal involvement, it is surprising that Hartl et al. found no associations of these antibodies with anti-DNase1L3 antibodies, unless a significant number of patients with renal disease were seronegative for antibodies to dsDNA and C1q. Here, DNASE1L3 is linked to kidney disorder.