While we found a striking association between anti-DNase1L3 and anti-dsDNA antibodies, which is explained in part by the presence of double reactive antibodies to DNase1L3 and dsDNA, it is puzzling that a recent study by Hartl et al.21 did not seem to support this finding, even though both studies found that antibodies to DNase1L3 were significantly linked to renal disease in SLE. Here, DNASE1L3 is linked to kidney disorder.