Indeed, the only association described by Hartl et al. with anti-DNase1L3 antibodies was renal involvement, which is likely explained by the fact that their cohort was highly enriched in patients with renal disease (87/120, 72%) and antibodies to DNase1L3 were only determined in a subset of these patients (57/120, 48%)21, limiting their capacity to find other clinical and serological associations described in our study. Here, DNASE1L3 is linked to kidney disorder.