Targeted metabolomics identified energy metabolites of lung adenocarcinoma cells and found that KCNK3 can inhibit proliferation and glucose metabolism through activation AMPK/TXNIP pathways, indicating KCNK3 may be a potential therapeutic target.647 The authors examined a total of 202 relationship features between various cancers and metabolites, and showed gamma-glutamylisoleucine, 7-alpha-hydroxy-3-oxo-4-cholestenoate, gamma-glutamylleucine, and 1-oleoylglycerophosphocholine were the most dangerous metabolites for ovarian cancer, lung cancer, glioma and breast cancer, respectively. This evidence concerns the gene KCNK3 and central nervous system cancer.