Aberrant expression of CRL4B has been reported in a variety of diseases and is highly expressed in several solid tumors, where it promotes tumorigenesis by affecting tumor suppressors.[25] Herein, the PRMT6/PARP1/CRL4B complex modified H3R2me2a and H2AK119ub leading to the disruption of circadian rhythms and transcriptional repression of key genes within the DNA repair pathway, including the tumor suppressor genes PER1 and PER3. Here, PRMT6 is linked to neoplasm.