The clock genes that elevate c‐Myc expression contribute to cancer progression by promoting cell proliferation and metabolic dysregulation.[31] Meanwhile, it is worth noting that in the current study, PRMT6/PARP1 knockdown obstructed breast cancer proliferation and metastasis by deregulating the transcriptional repression of PER3, however, PER3 knockdown rescued the inhibition of cancer progression. The gene discussed is CLOCK; the disease is breast cancer.