RELN and autism: Moreover, heterozygous reeler mice and Reelin ΔC-KI mice exhibit similar neurochemical, behavioral, and cognitive abnormalities to those observed in autism or schizophrenia (Costa et al., 2001; Tremolizzo et al., 2002; Carboni et al., 2004; Nullmeier et al., 2011; Sakai et al., 2016; Sánchez-Hidalgo et al., 2022).