Similar to the Dab1 gene, the Reelin gene is also known to exhibit haploinsufficiency (Liu et al., 2001; Carboni et al., 2004; Qiu et al., 2006; Nullmeier et al., 2011; Bouamrane et al., 2016; L. Wang et al., 2019), and reduced Reelin levels have been observed in the brains of patients with schizophrenia (Impagnatiello et al., 1998; Guidotti et al., 2000), bipolar disorder (Guidotti et al., 2000), autism (Fatemi et al., 2001, 2005), and Alzheimer’s disease (Chin et al., 2007). This evidence concerns the gene DAB1 and early-onset autosomal dominant Alzheimer disease.