POU2F3 and Kallmann syndrome: Furthermore, mice in which both the SCC system (TrpM5-KO, Gnat3-KO, and Skn1a-KO), MCs, and the olfactory system (methimazole-induced anosmia) were disrupted, showed no difference in response to Den, highlighting and validating the partial involvement of the sense of smell in the avoidance behavior to nebulized Den (Fig. 8A; Extended Data Fig. 8-1B–D).