There have been studies that reported significantly up-regulated miR-146a in human AD-affected temporal lobe (Wang et al, 2016; Pogue & Lukiw, 2018) and hippocampus (Jaber et al, 2017), miR-125b in human AD-affected temporal lobe (Brodmann area 22) (Pogue & Lukiw, 2018) and frontal cortex (Brodmann areas 6 and 8) (Banzhaf-Strathmann et al, 2014), miR-34a in human AD-affected temporal lobe (Sarkar et al, 2016; Jaber et al, 2017; Pogue & Lukiw, 2018), and miR-342 in the whole brain of APP-PS1 mice (Wang et al, 2017). The gene discussed is PSEN1; the disease is Alzheimer disease.