c-Abl was proposed as a target for disease-modifying therapy for PD, with Abl inhibitors like nilotinib displaying neuroprotective activity against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mice (Karuppagounder et al, 2014). Here, ABL1 is linked to Parkinson disease.