In a study by Jiang et al., CRC‐derived exosomes containing ANGPTL1 proteins attenuated liver metastasis and impeded vascular leakiness in a liver PMN by regulating KCs secretion pattern and decreasing its MMP9 levels by inhibiting the Janus kinase (JAK2)‐STAT3 signalling pathway; however, whether exosomal ANGPTL1 affected vascular permeability by directly or indirectly affecting endothelial cells remained unclear.84 The gene discussed is STAT3; the disease is colorectal carcinoma.