PDAC‐derived exosomal Ezrin (EZR) promoted PDAC liver metastasis by modulating macrophage polarization into immune‐suppressive M2 phenotype, and EZR knockdown in PDAC‐derived exosomes attenuated the potential of polarizing macrophages into M2 phenotype, which was accompanied with a decrease in the degree of liver metastasis in the PDAC animal model,96 suggesting that exosomal EZR may be another potential therapeutic target to combat liver metastatic disease. The gene discussed is EZR; the disease is metastatic neoplasm.