They also demonstrated that exosomal miR‐934 induced M2 macrophage polarization via downregulating PTEN expression and activating the phosphoinositide‐3‐kinase (PI3K)/AKT signalling pathway, and polarized M2 macrophages induced liver PMN formation and promoted liver metastasis in CRC by activating the CXCL13/CXCR5/NFκB/p65/miR‐934 positive feedback loop.99 Here, AKT1 is linked to colorectal carcinoma.