Sun et al. discovered that exosomal miR‐135a‐5p promoted CRC cell adhesion by activating the LATS2‐YAP1/TEAD1‐MMP7 pathway and inhibited CD30‐mediated CD4+ T activation, thereby selectively facilitating the formation of an immunosuppressive PMN for CRC liver metastases (CRLM). Here, YAP1 is linked to colorectal carcinoma.