Li et al. recently showed that engineered bone marrow MSC‐derived exosomes that were transfected with small interfering RNA against GRP78 combined with Sorafenib also inhibit the growth and invasion of HCC in vitro and liver metastasis of HCC in vivo,141 which suggested that MSC‐derived exosomes hold the promise of emerging as an efficient delivery system in liver metastatic disease. Here, HSPA5 is linked to hepatocellular carcinoma.