Ji et al. also showed that CRC cell‐derived integrin beta‐like 1 (ITGBL1)‐enriched exosomes were directly transferred to the liver, and they activated HSCs by binding to tumour necrosis factor alpha‐induced protein 3 (TNFAIP3) and then activated the nuclear factor kappa light chain enhancer of activated B cells (NF‐κB) signalling pathway, accompanied by the secretion of high levels of cytokines, such as IL‐6 and IL‐8, to create a fibrotic PMN and promote CRC stemness, aggressiveness, EMT, and liver metastasis.65 This evidence concerns the gene NFKB1 and colorectal carcinoma.