In particular, CRC cell‐derived exosomal miR‐25‐3p, miR‐130b‐3p, and miR‐425‐5p could also be transferred into macrophages to promote M2 polarization by regulating PTEN via activating the PI3K/AKT signalling pathway. The gene discussed is AKT1; the disease is colorectal carcinoma.