Additionally, CRC‐derived exosomes harbouring miR‐221/222 induced liver stromal cells to secret hepatocyte growth factors (HGFs) by suppressing serine protease inhibitor Kunitz type 1 (SPINT1) expression, providing a hospitable liver PMN for the aggressiveness of CRC cells.66 This evidence concerns the gene SPINT1 and colorectal carcinoma.