It has been suggested that an increased vulnerability to the SARS-CoV-2 virus and a more severe disease course are due to the higher risk of exacerbations by viral infections.19 In another study, it was suggested that accumulated eosinophils and type II inflammation cytokines (IL-4, IL-5, and IL-13) were protective.19,20 In the present study, no significant differences were detected in the disease severity (p=1.000), hospitalization (p=0.485), admission to ICUs (p=1.000), and mortality (p=1.000) between the patients with and without asthma. This evidence concerns the gene IL4 and viral infectious disease.