Similarly, 10-80 μM of resveratrol for 48 hours inhibited the MCF-7 and MDA-MB-231 breast cancer cells by binding to and activating estrogen receptor.43 In addition, in vitro study used in an animal model showed that resveratrol inhibited the tumor growth at a dose of 625 mg/kg.44 In addition to the chemopreventive and chemoprotective effects, resveratrol possesses a very high antioxidant activity by endogenous and exogenous mechanisms.45-48. This evidence concerns the gene ESR1 and breast carcinoma.