CD8A and type 2 diabetes mellitus: In one study, no differences in the levels of CD4 and CD8 in patients with T2DM and healthy individuals were observed.13 The findings of another study suggested that the levels of both CD4 and CD8 were higher in T2DM patients than in healthy individuals.23 Furthermore, CD4 and CD8 T-cell phenotyping analysis carried out in yet another study showed that there was a significant decrease in both CD4 and CD8 in T2DM patients compared to healthy individuals.24 Nevertheless, our findings suggest that the T-lymphocyte response is impaired in patients with T2DM.