Aprataxin (APTX), the product of the causative gene for hereditary neurogenerative syndromes Ataxia-oculomotor apraxia 1 and early onset ataxia with oculomotor apraxia and hypoalbuminemia, has an enzymatic activity of removing adenosine monophosphate from DNA 5′-end, which arises from abortive ligation by DNA ligases. This evidence concerns the gene APTX and Hypoalbuminemia.