NFE2L2 and cancer: Thus, we conclude that Nrf2 activation leads to an increase in glucose uptake in neurons and astrocytes and that glucose consumption is prioritized towards bioenergetic needs when glucose is limited, but metabolized towards PPP/NADPH when glucose stimulation is stimulated (as with OV).This is in contrast with results observed in other cell lines with very different metabolism, such as cancer cells, where Nrf2 redirects glucose to anabolic pathways to support cell proliferation [9].