Strikingly, examining the source of collagen gene expression (COL1A1, COL1A2, COL3A1, COL6A1, COL8A1, COL10A1) provided clarity that the majority of genes expressed in the tumor samples represent transcripts of the MSC-related component of the tissue microenvironment (Fig 5C). This evidence concerns the gene COL8A1 and neoplasm.