CASP3 and Cerebral ischemia: For instance, resveratrol has a neuroprotective effect against cerebral ischemia/reperfusion injury by up-regulating the expression of p-JAK2, p-STAT3, p-AKT, p-mTOR, and Bcl2, and down-regulating the expression of cleaved caspase-3 and Bax [62].