Molecularly, conditioned cells displayed E-cadherin downregulation and N-cadherin overexpression, indicating a shift towards an intermediate EMT state (Odero-Marah et al. 2018); in support of this observation, an increase in the levels of Snail, the master regulator of E-/N-switch during PCa dedifferentiation (Smith and Odero-Marah 2012), was also found (Fig. 3B). This evidence concerns the gene SNAI1 and posterior cortical atrophy.