The ALDH2 gene, an important genetic factor, is not only associated with the risk of digestive tumors associated with alcohol consumption (Suo et al. 2019; Hidaka et al. 2015; Sakamoto et al. 2006) but also contributes to the prevention of alcohol abuse (Shen et al. 1863), ischemia (Liu et al. 2015; Sun et al. 2014), metabolic disorders (Wang et al. 2016), and other adverse factors causing cardiac dysfunction. Here, ALDH2 is linked to metabolic disease.