To investigate the mechanism of activation of the Keap1-Nrf2 pathway during HCMV infection, p62 phosphorylation was measured at Ser349 (S349; located in the Keap1-interacting domain [KIR]) and Ser403 (S403; located at the ubiquitin-associated domain [UBA]). The gene discussed is KEAP1; the disease is cytomegalovirus infection.