DYRK1A and Dravet syndrome: To better understand the contribution of triplicated genes from the Dp3Tyb region on trabecular phenotypes associated with DS, we analyzed the Dp4Tyb, Dp5Tyb and Dp6Tyb lines (including littermate controls) that split the Dp3Tyb duplication into three separate regions, with only Dp5Tyb mice containing three copies of Dyrk1a (Fig. 1).