In detail, beside to the presence of distinct canonical CC gene signaling as TGF‐b, RTK‐RAS‐PIK3K,35 cell cycle, and the up‐regulation/down‐regulation of biological pathways related to cell cycle and metabolic processes, our results showed different immune cell populations within subgroups identifying in both ICC and ECC a subgroup (subgroup A) of tumors characterized by an immune exhausted tumor microenvironment. The gene discussed is TGFB1; the disease is intrahepatic cholangiocarcinoma.