To conclude, through animal and cell experiments, this study highlighted for the first time that TP protected podocytes from OS and pyroptosis in DN by activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome pathway, which further clarified the mechanism of TP in reducing DN and provided references and therapeutic targets for new therapeutic drugs for DN. This evidence concerns the gene NFE2L2 and liver dysplastic nodule.