MAPT and supranuclear palsy, progressive, 1: The sequence of atrophy in the ‘subcortical’ subtype broadly mirrors the sequential spread of tau pathology proposed by Kovacs et al. in their post-mortem PSP-RS staging system and is consistent with other in vivo disease progression models of PSP-RS.25,51 Whilst Scotton et al. 25 used an event-based modelling approach on PSP-RS cases to identify this sequence, Saito et al. 51 applied SuStaIn to a small cohort of PSP-RS and CBS cases.